Marine Drugs (Feb 2022)

Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their <sup>13</sup>C-NMR Spectroscopic Data Characteristics

  • Fahd M. Abdelkarem,
  • Mohamed E. Abouelela,
  • Mohamed R. Kamel,
  • Alaa M. Nafady,
  • Ahmed E. Allam,
  • Iman A. M. Abdel-Rahman,
  • Ahmad Almatroudi,
  • Faris Alrumaihi,
  • Khaled S. Allemailem,
  • Hamdy K. Assaf

DOI
https://doi.org/10.3390/md20020139
Journal volume & issue
Vol. 20, no. 2
p. 139

Abstract

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Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using 13C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research.

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