Relationship between polymorphism of beta 1 adrenergic receptor R389G gene and intraocular pressure in patients with POAG

Abstract

AIM: To investigate the relationship between adrenergic receptor(AR)R389G gene polymorphism and changes in intraocular pressure in patients with primary open angle glaucoma(POAG). METHODS: We selected 100 patients with newly diagnosed POAG from January 2015 to February 2017 in our hospital. The patient's intraocular pressure was measured at 6:00, 12:00, 18:00, and 24:00 daily and the mean value was calculated. Patients with mean intraocular pressure ≥30mmHg were included in Group A(44 patients), patients with mean intraocular pressure RESULTS: The frequency of GG genotype in Group A(27.3%)was significantly higher than that in Group B(8.9%)(PPPCONCLUSION: The β1AR R389G gene polymorphism is closely related to POAG and is an independent risk factor for increased intraocular pressure in patients with POAG.

Keywords

• β1 adrenergic receptor
• gene polymorphism
• primary open angle glaucoma
• intraocular pressure
• intraocular pressure