Nature Communications (Oct 2018)
Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
- Jessie Qiaoyi Liang,
- Narcissus Teoh,
- Lixia Xu,
- Sharon Pok,
- Xiangchun Li,
- Eagle S. H. Chu,
- Jonathan Chiu,
- Ling Dong,
- Evi Arfianti,
- W. Geoffrey Haigh,
- Matthew M. Yeh,
- George N. Ioannou,
- Joseph J. Y. Sung,
- Geoffrey Farrell,
- Jun Yu
Affiliations
- Jessie Qiaoyi Liang
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- Narcissus Teoh
- Liver Research Group, Australian National University Medical School at the Canberra Hospital
- Lixia Xu
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- Sharon Pok
- Liver Research Group, Australian National University Medical School at the Canberra Hospital
- Xiangchun Li
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- Eagle S. H. Chu
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- Jonathan Chiu
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- Ling Dong
- Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University
- Evi Arfianti
- Liver Research Group, Australian National University Medical School at the Canberra Hospital
- W. Geoffrey Haigh
- Department of Gastroenterology and Hepatology, Veterans Affairs Puget Sound Health Care System and University of Washington
- Matthew M. Yeh
- Department of Pathology, University of Washington School of Medicine
- George N. Ioannou
- Department of Gastroenterology and Hepatology, Veterans Affairs Puget Sound Health Care System and University of Washington
- Joseph J. Y. Sung
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- Geoffrey Farrell
- Liver Research Group, Australian National University Medical School at the Canberra Hospital
- Jun Yu
- Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-018-06931-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.
