Frontiers in Neuroscience (Nov 2023)

Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study

  • Sandra P. Smieszek,
  • Alyssa R. Kaden,
  • Caroline E. Johnson,
  • Jennifer L. Brzezynski,
  • Changfu Xiao,
  • Christos M. Polymeropoulos,
  • Gunther Birznieks,
  • Helene A. Emsellem,
  • Helene A. Emsellem,
  • Mihael H. Polymeropoulos

DOI
https://doi.org/10.3389/fnins.2023.1287514
Journal volume & issue
Vol. 17

Abstract

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We present a case of an adult female diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD) and Optic Nerve Hypoplasia (ONH), with a confirmed delayed Dim Light Melatonin Onset (DLMO), who reports the inability to fall asleep at their desired bedtime and obtain adequate sleep nightly, despite the ability to have a full night’s sleep when not required to be up at a specific time for societal requirements. The participant was enrolled in an 11-month Open-Label Extension (OLE) following the randomized portion of a clinical study and was successfully treated with tasimelteon. DSWPD symptoms were resolved, and their previously delayed sleep-wake cycle was advanced.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04652882, identifier NCT04652882.

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