Nature Communications (Feb 2022)

Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4

  • M. J. Gutbrod,
  • B. Roche,
  • J. I. Steinberg,
  • A. A. Lakhani,
  • K. Chang,
  • A. J. Schorn,
  • R. A. Martienssen

DOI
https://doi.org/10.1038/s41467-022-28554-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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While RNA interference is conserved across species, small RNA pathways are very diverse. In this study, Gutbrod et al. find that non-canonical roles of Dicer in genome stability are in fact deeply conserved from yeast to humans.