Mitral Annular Calcification and Thromboembolic Risk
Paula Cristina Morariu,
Daniela Maria Tanase,
Diana Elena Iov,
Oana Sîrbu,
Alexandru Florinel Oancea,
Cornel Gabriel Mircea,
Cristina Petronela Chiriac,
Genoveva Livia Baroi,
Ionela-Daniela Morariu,
Cristina Gena Dascălu,
Laurenţiu Şorodoc,
Mariana Floria
Affiliations
Paula Cristina Morariu
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Daniela Maria Tanase
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Diana Elena Iov
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Oana Sîrbu
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Alexandru Florinel Oancea
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Cornel Gabriel Mircea
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Cristina Petronela Chiriac
Medical Clinic, “Sf. Spiridon” Emergency Hospital, 700111 Iasi, Romania
Genoveva Livia Baroi
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Ionela-Daniela Morariu
Department of Environmental and Food Chemistry, “Grigore T. Popa” University of Medicine and Pharmacy Iași, 700111 Iasi, Romania
Cristina Gena Dascălu
Department of Medical Informatics and Biostatistics, Faculty of Dental Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Laurenţiu Şorodoc
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Mariana Floria
Department of Internal Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Thromboembolic (TE) risk scores used for atrial fibrillation (AF) patients do not include mitral annular calcification (MAC) as a potential indicator of vascular disease. This research evaluated the correlation between MAC and TE risk scores (CHADS2 and CHA2DS2-VASc). We compared TE risk score values and clinical and echocardiographic data in patients with and without MAC. We included, prospectively, 103 patients: 40.8% with AF, 83.5% with hypertension, 30.1% with type II diabetes mellitus, 79.6% with chronic heart failure, and 7.8% with a history of stroke. We identified MAC in 50.5% of patients. The mean CHADS2 and CHA2DS2-VASc scores were 2.56 ± 1.135 and 4.57 ± 1.61, respectively. In MAC patients, both scores tended to increase significantly compared with the control (2.88 ± 1.114 versus 2.24 ± 1.06, p = 0.005, and 5.21 ± 1.51 versus 3.92 ± 1.46, p p = 0.01). The presence of MAC was a risk factor for vascular disease (OR = 2.47, χ2 = 34.32, p < 0001). Conclusions: The presence of MAC is associated with greater TE risk scores and a higher risk of vascular disease. It appears that adding MAC as a vascular disease parameter to TE risk scores may have benefits for patients by improving their predictive value.
