Risk Prediction of Early and Late Acquired Glomerular and Tubular Dysfunctions in Patients with Disorders of Carbohydrate Metabolism

Abstract

The purpose of this study was to create a new system for predicting the risk of glomerular and tubular dysfunctions (GTD) in patients with disorders of carbohydrate metabolism (DCM) based on standard parameters and new molecular markers for the development of kidney damage in patients with impaired glucose tolerance (IGT) and T2DM patients with diabetic nephropathy (DN). Material and Methods: The study included 69 patients: 16 patients with IGT (Group 1), 28 T2DM patients with MAU (Group 2), and 25 T2DM patients with MacAU (Group 3), according to the inclusion/exclusion criteria in the research. All patients were stratified by the MDRD. The control group (Group 4) included 11 healthy individuals. The duration of DN was 10.5 years. At the stage of data collection and screening, the standard methods of identification of IGT, DM and DN were applied. Additional methods are included quantitative analysis of the level of α-GST and π-GST, MMP-9 in urine by ELISA. Result: Analysis of the correlation interactions of the level of standard risk factors for the development of renal damage in patients with IGT and DN with the level of new molecular markers in urine and blood allows us to identify and introduce into clinical practice new screening tests reflecting the key molecular interactions that underlie the development of GTD in patients with DCM.

Keywords

• diabetic nephropathy
• glomerular dysfunctions
• tubular dysfunctions
• molecular markers
• impaired glucose tolerance