Deeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology

Abstract

Highlight 1. In this review, after summarizing the general roles of intestinal physiology in the pathology of hypertension in detail, we point out the potential use of metabolism of intestinal flora and immune factors in its treatment. 2. We put the interactions of hypertension and a wide-array of cytokine together with metabolites of intestinal flora and intestinal cells, and show the limitations of present researches. 3. We give specific introduction to recent findings of MCP-1, IL-6, TNF-β and IL-10 in hypertension and show underlying effect in the pathogenesis of effects on kidney, cardiovascular and other tissues. 4. As the well-recognized pivotal control of hypertension, interleukins in the mediation of signals transmitted through cardiovascular from digestive tract, whose mechanisms remain largely covered and called for more investigations to address the important issue.

Keywords

• Immune factors
• IL-17
• Gut microbiota
• Hypertension
• MCP-1
• TGF-β