Pathophysiology of Infantile Spasms

Abstract

An age-specific endogenous-convulsant hypothesis implicating corticotropin-releasing hormone (CRH), an excitant neuropeptide suppressed by ACTH/steroids, is proposed for the pathophysiology of massive infantile spasms in a report from the University of Southern California, Los Angeles, CA.

Keywords

• corticotropin-releasing hormone
• endogenous-convulsant hypothesis
• brain-stem circuits