The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

Abstract

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.

Keywords

• Toll-like receptor 4
• Cytokine
• cytometric bead array technology
• aqueous humor
• Anterior Uveitis