Electro-oxidative quinylation of sulfides to sulfur ylides in batch and continuous flow
Xiangxing Huang,
Yifei Yao,
Xing Yin,
Wenjing Guan,
Chengcheng Yuan,
Zheng Fang,
Hong Qin,
Chengkou Liu,
Kai Guo
Affiliations
Xiangxing Huang
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
Yifei Yao
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
Xing Yin
Intervention Therapy Department, General Hospital of Eastern Theater Command, Nanjing 222042, China
Wenjing Guan
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
Chengcheng Yuan
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
Zheng Fang
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
Hong Qin
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
Chengkou Liu
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China; Corresponding author
Kai Guo
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China
Summary: An unprecedented strategy for preparing a series of sulfur ylides through electro-oxidative quinylation of sulfides in batch and continuous flow has been developed. Good to excellent yields were obtained with excellent functional group compatibility and good concentration tolerance under exogenous oxidant- and transition metal-free conditions. Advantageously, this electrosynthesis methodology was scalable with higher daily production and steady production was achieved attributing to the use of micro-flow cells.
