Applied Sciences (Jun 2021)

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

  • Alessia Catalano,
  • Maria Stefania Sinicropi,
  • Domenico Iacopetta,
  • Jessica Ceramella,
  • Annaluisa Mariconda,
  • Camillo Rosano,
  • Elisabetta Scali,
  • Carmela Saturnino,
  • Pasquale Longo

DOI
https://doi.org/10.3390/app11136027
Journal volume & issue
Vol. 11, no. 13
p. 6027

Abstract

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Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.

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