Retention of paternal DNA methylome in the developing zebrafish germline

Ksenia Skvortsova; Katsiaryna Tarbashevich; Martin Stehling; Ryan Lister; Manuel Irimia; Erez Raz; Ozren Bogdanovic

doi:10.1038/s41467-019-10895-6

Nature Communications (Jul 2019)

Retention of paternal DNA methylome in the developing zebrafish germline

Ksenia Skvortsova,
Katsiaryna Tarbashevich,
Martin Stehling,
Ryan Lister,
Manuel Irimia,
Erez Raz,
Ozren Bogdanovic

Affiliations

Ksenia Skvortsova: Genomics and Epigenetics Division, Garvan Institute of Medical Research
Katsiaryna Tarbashevich: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Martin Stehling: Flow Cytometry Unit, Max-Planck-Institute for Molecular Biomedicine
Ryan Lister: ARC CoE Plant Energy Biology, School of Molecular Sciences, The University of Western Australia
Manuel Irimia: Centre for Genomic Regulation, The Barcelona Institute for Science and Technology
Erez Raz: Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster
Ozren Bogdanovic: Genomics and Epigenetics Division, Garvan Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-019-10895-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Germ cells are the means of transferring genetic information to the next generation. Here the authors characterise the DNA methylomes of zebrafish primordial germ cells and find that, unlike mammals, the zebrafish germ cells do not undergo genome-wide DNA demethylation but rather retain paternal DNA methylation patterns

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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