Frontiers in Neurology (Jun 2020)

Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies

  • Jae-Won Hyun,
  • Young Nam Kwon,
  • Young Nam Kwon,
  • Sung-Min Kim,
  • Hye Lim Lee,
  • Woo Kyo Jeong,
  • Woo Kyo Jeong,
  • Hye Jung Lee,
  • Hye Jung Lee,
  • Byoung Joon Kim,
  • Byoung Joon Kim,
  • Seung Woo Kim,
  • Ha Young Shin,
  • Hyun-June Shin,
  • Sun-Young Oh,
  • So-Young Huh,
  • Woojun Kim,
  • Min Su Park,
  • Jeeyoung Oh,
  • Hyunmin Jang,
  • Na Young Park,
  • Min Young Lee,
  • Su-Hyun Kim,
  • Ho Jin Kim

DOI
https://doi.org/10.3389/fneur.2020.00396
Journal volume & issue
Vol. 11

Abstract

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Objectives: To compare the frequency of area postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.Methods: APS is defined as acute or subacute, single or combined, episodic or constant nausea, vomiting, or hiccups, persisting for at least 48 h, which cannot be attributed to any other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodies from 10 hospitals.Results: The study population comprised Korean adults (≥18 years). At the time of disease onset, 14.9% (41/274) adults with AQP4 antibodies had APS, while none of the participants with MOG antibodies developed APS (p < 0.001). During the course of the disease, 17.2% (47/274) adults with AQP4 antibodies had APS in contrast to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001).Conclusions: APS, one of the core clinical characteristics of individuals with AQP4 antibodies, is an extremely rare manifestation in Korean adults with MOG antibodies.

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