The effects of mid and long-term endurance exercise on heart angiogenesis and oxidative stress

Abstract

Objective(s): Long-term, irregular endurance exercise may result in disturbance to the angiogenesis of heart muscles and blood supply. The aim of the present study is to evaluate the effects of mid- and long-term endurance exercise on the process of angiogenesis.Materials and Methods: Eighteen male Wister rats of 220±10 g, were randomly assigned to three groups of 6 rats including: Control, Mid, and Long Group. After the training sessions, the rats were weighed and sacrificed.Results: In comparison to the Control Group, the both groups, indicated remarkable increase in the weight of heart and significantly higher serum LDH and CK activity (P

Keywords

• Angiopoietin-1
• Endurance Exercise
• HDAC4
• MMP-2
• VEGF-B