PHARMACOLOGICAL STUDY OF NEPHROPROTECTIVE ACTION OF LIPOSOMAL ESSENTIAL PHOSPHOLIPIDS ON THE MODEL OF ENDOTHELIAL DYSFUNCTION IN PREGNANT RATS

Abstract

Purpose: to study the nephroprotective action of liposomal essential phospholipids on the model of endothelial dysfunction (experimental gestosis) in pregnant rats induced by inhibition of nitric oxide synthase.Materials and methods: endothelial dysfunction was caused by administration of Nω-nitro-L-arginin solution during gestation in pregnant rats. Study drugs: essential phospholipids and the reference drug molsidomine. The effect of treatment was evaluated by a blood pressure value, level of protein in urine and morphological study of kidney tissue.Results: essential phospholipids in liposomal form have significantly decreased high blood pressure, diminished proteinuria and normalized the morphological structure of kidney tissue in pregnant rats.Summary: nephroprotective effect of essential phospholipids liposomal form in endothelial dysfunction was found.

Keywords

• endothelial dysfunction
• gestosis
• essential phospholipids
• nephroprotective action
• nω-nitro-l-arginin