Endocrine and Metabolic Science (Nov 2020)
Pre-diabetes and NAFLD; A study of an Algerian population sample
Abstract
Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance.
