Frontiers in Endocrinology (Aug 2023)

Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications

  • Yuyan Zhu,
  • Yuyan Zhu,
  • Yuyan Zhu,
  • Xuan Xia,
  • Xuan Xia,
  • Xuan Xia,
  • Xuan Xia,
  • Qian He,
  • Qing-Ao Xiao,
  • Qing-Ao Xiao,
  • Decheng Wang,
  • Decheng Wang,
  • Decheng Wang,
  • Meirong Huang,
  • Meirong Huang,
  • Meirong Huang,
  • Meirong Huang,
  • Xiaolin Zhang,
  • Xiaolin Zhang

DOI
https://doi.org/10.3389/fendo.2023.1202463
Journal volume & issue
Vol. 14

Abstract

Read online

Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutralizing pathogen, NETosis plays a crucial role in diabetes and diabetes-related complications. In patients with diabetes, NETs-releasing products are significantly elevated in blood, and these findings confirm the association of NETosis and diabetic complications, including diabetic wound healing, diabetic retinopathy, and atherosclerosis. This article briefly summarizes the mechanisms of NETosis and discusses its contribution to the pathogenesis of diabetes-related complications and suggests new therapeutic targets by some small molecule compounds.

Keywords