Nature Communications (Oct 2017)

DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1

  • Jing Ting Wong,
  • Farzanah Akhbar,
  • Amanda Yunn Ee Ng,
  • Mandy Li-Ian Tay,
  • Gladys Jing En Loi,
  • Jun Wei Pek

DOI
https://doi.org/10.1038/s41467-017-00684-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.