A study on vestibular-evoked myogenic potentials via galvanic vestibular stimulation in normal people

Abstract

Objectives: The aim of our study is to examine vestibular-evoked myogenic potentials (VEMPs) elicited by the galvanic vestibular stimulation in the sternocleidomastoid muscle (SCM) in healthy subjects for clinical applications of auditory neuropathy or vestibular neuropathy in the future. Methods: We enrolled sixteen healthy subjects to record the average responses of SCM to galvanic vestibular stimulation (GVS) [current 3 mA; duration 1 ms] by electromyography (EMG). SPSS18.0 software was used to analyze the obtained data for mean and standard deviation. Results: In all healthy subjects mastoid-forehead galvanic vestibular stimulation produced a positive-negative biphasic EMG responses on SCM ipsilateral to the cathodal electrode. The latency of p13 was 11.7 ± 3.0 ms. The latency of n23 was 17.8 ± 3.4 ms. The amplitude of p13-n23 was 147.0 ± 69.0 μV. The interaural asymmetry ratio (AR) of p13, n23 latency and the amplitude was respectively 0.12 ± 0.09, 0.08 ± 0.08 and 0.16 ± 0.10. Discussions: Galvanic vestibular stimulation could elicit biphasic EMG responses from SCM via the vestibular nerve but not from the otolith organs. Galvanic stimulation together with air conducted sound (ACS) or bone conducted vibration (BCV) can elicit VEMPs and may enable the differentiation of retrolabyrinthine lesions from labyrinthine lesions in vestibular system.

Keywords

• Galvanic vestibular stimulation
• Vestibular nerve
• Vestibular-evoked myogenic potentials
• Sternocleidomastoid muscle
• Interaural asymmetry ratio (AR)