Nature Communications (Sep 2021)
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
- Kimiharu Takamatsu,
- Nobuyuki Tanaka,
- Kyohei Hakozaki,
- Ryohei Takahashi,
- Yu Teranishi,
- Tetsushi Murakami,
- Ryohei Kufukihara,
- Naoya Niwa,
- Shuji Mikami,
- Toshiaki Shinojima,
- Takashi Sasaki,
- Yusuke Sato,
- Haruki Kume,
- Seishi Ogawa,
- Kazuhiro Kakimi,
- Takashi Kamatani,
- Fuyuki Miya,
- Tatsuhiko Tsunoda,
- Eriko Aimono,
- Hiroshi Nishihara,
- Kazuaki Sawada,
- Takeshi Imamura,
- Ryuichi Mizuno,
- Mototsugu Oya
Affiliations
- Kimiharu Takamatsu
- Department of Urology, Keio University School of Medicine
- Nobuyuki Tanaka
- Department of Urology, Keio University School of Medicine
- Kyohei Hakozaki
- Department of Urology, Keio University School of Medicine
- Ryohei Takahashi
- Department of Urology, Keio University School of Medicine
- Yu Teranishi
- Department of Urology, Keio University School of Medicine
- Tetsushi Murakami
- Department of Urology, Keio University School of Medicine
- Ryohei Kufukihara
- Department of Urology, Keio University School of Medicine
- Naoya Niwa
- Department of Urology, Keio University School of Medicine
- Shuji Mikami
- Department of Diagnostic Pathology, Keio University Hospital
- Toshiaki Shinojima
- Department of Urology, Keio University School of Medicine
- Takashi Sasaki
- Center for Supercentenarian Medical Research, Keio University School of Medicine
- Yusuke Sato
- Department of Urology, Graduate School of Medicine, The University of Tokyo
- Haruki Kume
- Department of Urology, Graduate School of Medicine, The University of Tokyo
- Seishi Ogawa
- Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University
- Kazuhiro Kakimi
- Department of Immunotherapeutics, The University of Tokyo Hospital
- Takashi Kamatani
- Laboratory for Medical Science Mathematics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Fuyuki Miya
- Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)
- Tatsuhiko Tsunoda
- Laboratory for Medical Science Mathematics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Eriko Aimono
- Genomics Unit, Keio Cancer Center, Keio University School of Medicine
- Hiroshi Nishihara
- Genomics Unit, Keio Cancer Center, Keio University School of Medicine
- Kazuaki Sawada
- Center for Integrated Medical Research, Keio University School of Medicine
- Takeshi Imamura
- Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University
- Ryuichi Mizuno
- Department of Urology, Keio University School of Medicine
- Mototsugu Oya
- Department of Urology, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25865-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Targeting the inhibitory receptors (IRs) LAG-3, TIM-3 and TIGIT is a promising immune-oncology approach and the identification of biomarkers of response is crucial. Here, the authors apply automated single-cell count for these IRs in human renal cell carcinoma and investigate the immunogenomic landscape of the disease.
