Nature Communications (Sep 2019)
A cell fitness selection model for neuronal survival during development
- Yiqiao Wang,
- Haohao Wu,
- Paula Fontanet,
- Simone Codeluppi,
- Natalia Akkuratova,
- Charles Petitpré,
- Yongtao Xue-Franzén,
- Karen Niederreither,
- Anil Sharma,
- Fabio Da Silva,
- Glenda Comai,
- Gulistan Agirman,
- Domenico Palumberi,
- Sten Linnarsson,
- Igor Adameyko,
- Aziz Moqrich,
- Andreas Schedl,
- Gioele La Manno,
- Saida Hadjab,
- François Lallemend
Affiliations
- Yiqiao Wang
- Department of Neuroscience, Karolinska Institutet
- Haohao Wu
- Department of Neuroscience, Karolinska Institutet
- Paula Fontanet
- Department of Neuroscience, Karolinska Institutet
- Simone Codeluppi
- Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Natalia Akkuratova
- Department of Physiology and Pharmacology, Karolinska Institutet
- Charles Petitpré
- Department of Neuroscience, Karolinska Institutet
- Yongtao Xue-Franzén
- Department of Neuroscience, Karolinska Institutet
- Karen Niederreither
- Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, Inserm U964, Université de Strasbourg
- Anil Sharma
- Department of Neuroscience, Karolinska Institutet
- Fabio Da Silva
- Université Côte d’Azur, Inserm, CNRS, iBV
- Glenda Comai
- Stem Cells & Development - Institut Pasteur - CNRS UMR3738
- Gulistan Agirman
- Department of Neuroscience, Karolinska Institutet
- Domenico Palumberi
- Department of Neuroscience, Karolinska Institutet
- Sten Linnarsson
- Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Igor Adameyko
- Department of Physiology and Pharmacology, Karolinska Institutet
- Aziz Moqrich
- Aix-Marseille-Université, CNRS, Institut de Biologie du Développement de Marseille (IBDM), UMR 7288
- Andreas Schedl
- Université Côte d’Azur, Inserm, CNRS, iBV
- Gioele La Manno
- Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
- Saida Hadjab
- Department of Neuroscience, Karolinska Institutet
- François Lallemend
- Department of Neuroscience, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-12119-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Programmed cell death is an important part of tissue development, and traditionally it is considered that neuronal death is a stochastic process in response to neurotrophic factor deprivation. Here the authors show that for TrkC+ proprioreceptors, which neurons die is predetermined molecularly by how much TrkC is present, as well as by a gene expression signature.
