A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells
Zi-Hua Zheng,
Zhi-Ke Li,
Lin-Jiang Song,
Qi-Wei Wang,
Qing-Fei Huang,
Li Yang
Affiliations
Zi-Hua Zheng
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
Zhi-Ke Li
Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
Lin-Jiang Song
Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
Qi-Wei Wang
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
Qing-Fei Huang
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
Li Yang
Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
A colorimetric and turn-on fluorescent probe 1 bearing triphenylamine-thiophene and dicyanovinyl groups has been synthesized and used to detect cyanide anion via a nucleophilic addition reaction. Probe 1 exhibited prominent selectivity and sensitivity towards CN− in aqueous media, even in the presence of other anions such as S2−, HS−, SO32−, S2O32−, S2O82−, I−, Br−, Cl−, F−, NO2−, N3−, SO42−, SCN−, HCO3−, CO32− and AcO−. Moreover, a low detection limit (LOD, 51 nM) was observed. In addition, good cell membrane permeability and low cytotoxicity to HeLa cells were also observed, suggesting its promising potential in bio-imaging.
