iScience (Feb 2025)
The role of platelet-rich plasma in biomedicine: A comprehensive overview
- Zhixin Zhang,
- Peng Liu,
- Xinmiao Xue,
- Zhiyu Zhang,
- Li Wang,
- Yvke Jiang,
- Chi Zhang,
- Hanwen Zhou,
- Shuhan Lv,
- Weidong Shen,
- Shiming Yang,
- Fangyuan Wang
Affiliations
- Zhixin Zhang
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Peng Liu
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Xinmiao Xue
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Zhiyu Zhang
- School of Physics and Optoelectronic Engineering Xidian University, Xi’an 710071, China
- Li Wang
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Yvke Jiang
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Chi Zhang
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Hanwen Zhou
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
- Shuhan Lv
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
- Weidong Shen
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
- Shiming Yang
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; Corresponding author
- Fangyuan Wang
- Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Corresponding author
- Journal volume & issue
-
Vol. 28,
no. 2
p. 111705
Abstract
Summary: Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role in clinical practice. This blood derivative, enriched with platelet components, has shown great potential for promoting tissue repair and regeneration. Its wide range of applications and the presence of anti-inflammatory and growth-promoting factors make it a valuable tool in the field of biomedicine. The exploration of PRP in clinical settings has been gaining momentum. Despite its cost-effectiveness, safety, and therapeutic efficacy, the widespread clinical adoption of PRP has been hindered by the absence of consistent preparation standards and standardized treatment protocols. This article provides a comprehensive analysis of the clinical uses, physiological roles, molecular mechanisms, and preparation techniques of PRP in biomedicine. The aim is to offer a thorough understanding of the potential applications and benefits of PRP in medical practice.
