Cancers (Apr 2021)

Prognostic Value of the Neutrophil-to-Lymphocyte Ratio before and after Radiotherapy for Anaplastic Thyroid Carcinoma

  • Jiyun Park,
  • Jun Park,
  • Jung-Hee Shin,
  • Young-Lyun Oh,
  • Hyun-Ae Jung,
  • Man-Ki Chung,
  • Jun-Ho Choe,
  • Yong-Chan Ahn,
  • Sun-Wook Kim,
  • Jae-Hoon Chung,
  • Tae-Hyuk Kim,
  • Jae-Myoung Noh

DOI
https://doi.org/10.3390/cancers13081913
Journal volume & issue
Vol. 13, no. 8
p. 1913

Abstract

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The neutrophil–lymphocyte ratio (NLR) is a marker of systemic inflammation, and its elevation has recently been associated with poor survival in many solid cancers. Leukocyte elevation and lymphocyte reduction are associated with a poor response to radiotherapy (RT). This study aimed to assess the prognostic value of NLR before and after RT for anaplastic thyroid carcinoma (ATC). This retrospective study analyzed 40 patients with ATC who received RT with available complete blood cell count data from November 1995 through May 2020 at Samsung Medical Center (Seoul, Korea). Patients were classified into two groups according to the NLR before and after RT. The median overall survival (OS) was 8.9 months (range, 3.5–18.2) in the low NLR group (p = 0.026). The OS curves differed significantly according to post-RT NLR (p = 0.036). A high NLR before and after RT may be significantly associated with poor OS in patients with ATC who receive RT.

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