Fate and distribution of orally-ingested CeO2-nanoparticles based on a mouse model: Implication for human health

Xingmao Ma; Xiaoxuan Wang; Lei Xu; Honglan Shi; Hu Yang; Kerstin K. Landrock; Virender K. Sharma; Robert S. Chapkin

doi:10.1016/j.seh.2023.100017

Soil & Environmental Health (Jun 2023)

Fate and distribution of orally-ingested CeO2-nanoparticles based on a mouse model: Implication for human health

Xingmao Ma,
Xiaoxuan Wang,
Lei Xu,
Honglan Shi,
Hu Yang,
Kerstin K. Landrock,
Virender K. Sharma,
Robert S. Chapkin

Affiliations

Xingmao Ma: Zachry Department of Civil and Environmental Engineering, Texas A&M University, College Station, TX, 77843, USA; Corresponding authors. Zachry Department of Civil and Environmental Engineering, Texas A&M University, College Station, TX, 77843, USA.
Xiaoxuan Wang: Zachry Department of Civil and Environmental Engineering, Texas A&M University, College Station, TX, 77843, USA
Lei Xu: Linda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA
Honglan Shi: Department of Chemistry and Center for Research in Energy and Environment, Missouri University of Science and Technology, Rolla, MO 65409, USA
Hu Yang: Linda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA
Kerstin K. Landrock: Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA; Program in Integrative Nutrition & Complex Diseases, Texas A&M University, College Station, TX, 77843, USA
Virender K. Sharma: Department of Environmental and Occupational Health, Texas A&M University, College Station, TX, 77843, USA
Robert S. Chapkin: Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA; Program in Integrative Nutrition & Complex Diseases, Texas A&M University, College Station, TX, 77843, USA; Corresponding authors. Zachry Department of Civil and Environmental Engineering, Texas A&M University, College Station, TX, 77843, USA.

DOI: https://doi.org/10.1016/j.seh.2023.100017
Journal volume & issue: Vol. 1, no. 2
p. 100017

Abstract

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The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO2NP) is commonly used in agriculture and is highly stable in the environment. As such, it has been used as a model chemical to investigate nanoparticle's distribution and clearance. Based on their estimated human exposure levels, 0.15–0.75 mg/kg body weight/day of CeO2NPs with different sizes and surface charges (30–50 nm with negative charge and 25 nm are unlikely to accumulate in mouse organ after oral intake, indicating limited impacts on human health.

Published in Soil & Environmental Health

ISSN: 2949-9194 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences; Medicine: Public aspects of medicine
Website: https://www.sciencedirect.com/journal/soil-and-environmental-health

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