LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

Changhao Chen; Wang He; Jian Huang; Bo Wang; Hui Li; Qingqing Cai; Feng Su; Junming Bi; Hongwei Liu; Bin Zhang; Ning Jiang; Guangzheng Zhong; Yue Zhao; Wen Dong; Tianxin Lin

doi:10.1038/s41467-018-06152-x

Nature Communications (Sep 2018)

LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

Changhao Chen,
Wang He,
Jian Huang,
Bo Wang,
Hui Li,
Qingqing Cai,
Feng Su,
Junming Bi,
Hongwei Liu,
Bin Zhang,
Ning Jiang,
Guangzheng Zhong,
Yue Zhao,
Wen Dong,
Tianxin Lin

Affiliations

Changhao Chen: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Wang He: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Jian Huang: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Bo Wang: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Hui Li: Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia
Qingqing Cai: Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
Feng Su: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Junming Bi: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Hongwei Liu: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Bin Zhang: Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital
Ning Jiang: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Guangzheng Zhong: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Yue Zhao: Department of Tumor Intervention, Sun Yat-sen University First Affiliated Hospital
Wen Dong: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital
Tianxin Lin: Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial Hospital

DOI: https://doi.org/10.1038/s41467-018-06152-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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