New Isocoumarins from the Marine Fungus <i>Phaeosphaeriopsis</i> sp. WP-26
Pei Wang,
Huifang Wang,
Juchun Yang,
Li Yang,
Caihong Cai,
Jingzhe Yuan,
Fei Wu,
Cuijuan Gai,
Wenli Mei,
Haofu Dai
Affiliations
Pei Wang
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Huifang Wang
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Juchun Yang
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Li Yang
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Caihong Cai
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Jingzhe Yuan
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Fei Wu
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Cuijuan Gai
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Wenli Mei
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Haofu Dai
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Five new isocoumarins, phaeosphaerins A–E (1–5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1–7 displayed weak neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
