Nature Communications (Jun 2022)

Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage

  • Konstantin Lutz,
  • Andrea Musumeci,
  • Christopher Sie,
  • Ezgi Dursun,
  • Elena Winheim,
  • Johannes Bagnoli,
  • Christoph Ziegenhain,
  • Lisa Rausch,
  • Volker Bergen,
  • Malte D. Luecken,
  • Robert A. J. Oostendorp,
  • Barbara U. Schraml,
  • Fabian J. Theis,
  • Wolfgang Enard,
  • Thomas Korn,
  • Anne B. Krug

DOI
https://doi.org/10.1038/s41467-022-31054-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The ontogeny of conventional and plasmacytoid dendritic cells (DC) and how these two cell types are related is not fully known. Here the authors identify a pool of bone marrow precursor cells expressing Ly6D Siglec-H and Zbtb46 that can differentiate into either cDC or pDC and show that type I IFN can limit cDC and favor pDC output from these precursors.