Frontiers in Aging Neuroscience (Aug 2016)

Association between hs-CRP levels and the outcomes of patients with small-artery occlusion

  • Ruiying Qiu,
  • Yuan Gao,
  • Dongzhe Hou,
  • Yajing Wang,
  • Changshen Yu,
  • Wanjun Wang,
  • Shoufeng Liu,
  • Chunlin Gao,
  • Xiaoguang Tong,
  • Jialing Wu

DOI
https://doi.org/10.3389/fnagi.2016.00191
Journal volume & issue
Vol. 8

Abstract

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Background: High-sensitivity C-reactive protein (hs-CRP) is not only a marker of inflammation but also a prognostic factor for ischemic stroke. The objective of our study was to investigative the association between hs-CRP levels and outcomes of patients with small-artery occlusion (SAO).Methods: We selected 718 participants diagnosed with SAO (according to Trial of Org 10172 in Acute Stroke Treatment classification) using the stroke registry of the Department of Neurorehabilitation of Tianjin HuanHu Hospital. Hs-CRP values at admission were classified into 3 categories: 2.77 mg/L) were at increased risk of poor outcome (adjusted odds ratio, 1.917; 95% CI, 1.050–3.500; P = 0.034), and more than twice the risk of poor outcome among patients in the younger subgroup (adjusted odds ratio, 2.092; 95% CI, 1.079–4.058; P = 0.029). These associations persisted after adjustment for confounding risk factors. However, hs-CRP levels were not significantly associated with outcome among patients in the elder subgroup.Conclusions: Elevated hs-CRP in patients with SAO is an independent predictor of poor prognosis; however, this association is only present in younger patients (< 75 years).

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