Study of co-relation between Transaminitis and fall in platelet counts in patients with Dengue Fever and its association with severity of clinical presentation

Abstract

Background: Dengue fever presents with varied presentations which include liver cell injury. This Liver injury manifests as Transaminitis which correlates with clinical severity. A severity of disease is associated with increased transaminases and sequential fall in platelet count which has been observed in this study. Objectives: To study the co relation between raised Liver enzymes and Thrombocytopenia in clinical spectrum of Dengue fever. Methods: In a tertiary referral hospital, 100 confirmed patients were enrolled and observational study was conducted over a period of 18 months. Detailed history, Physical examination done were recorded. Serial platelets counts and Aminotransferase levels were done. Patients were followed up till discharge. Data was analysed using approprate statistical tests. Results: SGOT was mildy increased in 28% of patients, moderately increased in 34% of patients, and severely increased in 38% of patients and SGPT was observed normal in 5%, mildly increased in 47% of patients, moderate increased 22% of patients, and severe increased in 27% of patients. Strong corelation was observed between severity of Transaminitis and Thrombocytopenia (p<0.001) Conclusion: Transaminitis is an important prognostic marker in Dengue fever and can be used early to distinguish between Dengue fever, Dengue hemorrhagic fever and Dengue shock syndrome at time of clinical presentation. The raise of SGOT and SGPT correlated proportionately with the Thrombocytopenia and the spectrum of disease severity.

Keywords

• dengue fever
• transaminitis
• thrombocytopenia
• dengue shock syndrome