Trans-regulatory variant network contributes to missing heritability
Vanessa Pereira,
Elena Kuzmin
Affiliations
Vanessa Pereira
Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada
Elena Kuzmin
Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada; Department of Human Genetics, Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Canada; Corresponding author
In a recent Cell Genomics article, Tsouris et al.1 analyze the transcriptomes of a large diallel panel of hybrids from Saccharomyces cerevisiae natural isolates to study cis- and trans-regulatory changes underlying gene expression variation. Vanessa Pereira and Elena Kuzmin discuss the authors’ findings and the wider context in missing heritability research in this preview.
