Amazon Rainforest Hidden Volatiles—Part I: Unveiling New Compounds from <i>Acmella oleracea</i> (L.) R.K. Jansen Essential Oil
Niko S. Radulović,
Marko Z. Mladenović,
Clarissa Silva Lima,
Elza Caroline Alves Müller,
Elizabeth Vianna Moraes da Costa,
Rozilene Valadares Martins,
Fabio Boylan
Affiliations
Niko S. Radulović
Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
Marko Z. Mladenović
Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
Clarissa Silva Lima
Department of Biological Sciences and Health, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil
Elza Caroline Alves Müller
Department of Biological Sciences and Health, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil
Elizabeth Vianna Moraes da Costa
Department of Biological Sciences and Health, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil
Rozilene Valadares Martins
Postgraduate Program in Health Sciences, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil
Fabio Boylan
School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, D02 PN40 Dublin, Ireland
Motivated by the culinary and ethnopharmacological use of Acmella oleracea (L.) R.K. Jansen, this study aimed to unveil new chemical compounds from its essential oil (EO). Acmella oleracea, known for its anesthetic and spicy properties, has been used in traditional medicine and cuisine, particularly in Northern Brazil. Through a detailed GC-MS analysis, 180 constituents were identified, including 12 tentatively identified long-chain α-keto esters of various acids. Additionally, 18 new esters were synthesized for structural verification. This research expands the known chemical diversity of A. oleracea EO, providing a basis for potential pharmacological applications. The identification of new natural products, including homologs and analogs of acmellonate, underscores the EO’s rich chemical profile and its potential for novel bioproduct development.
