Nature Communications (Aug 2016)
Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
- Lianhui Sun,
- Guangjian Fan,
- Peipei Shan,
- Xiaoying Qiu,
- Shuxian Dong,
- Lujian Liao,
- Chunlei Yu,
- Tingting Wang,
- Xiaoyang Gu,
- Qian Li,
- Xiaoyu Song,
- Liu Cao,
- Xiaotao Li,
- Yongping Cui,
- Shengping Zhang,
- Chuangui Wang
Affiliations
- Lianhui Sun
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Guangjian Fan
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Peipei Shan
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Xiaoying Qiu
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University
- Shuxian Dong
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University
- Lujian Liao
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University
- Chunlei Yu
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University
- Tingting Wang
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Xiaoyang Gu
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Qian Li
- School of Life Science & Technology, China Pharmaceutical University
- Xiaoyu Song
- Key Laboratory of Medical Cell Biology, College of Translational Medicine, China Medical University
- Liu Cao
- Key Laboratory of Medical Cell Biology, College of Translational Medicine, China Medical University
- Xiaotao Li
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University
- Yongping Cui
- Key Laboratory of Cellular Physiology Ministry of Education, Shanxi Medical University
- Shengping Zhang
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Chuangui Wang
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms12497
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of rRNA transcription and cell survival.
