Indonesian Journal of Chemistry (Dec 2021)

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

  • Ghina Izdihar,
  • Al Arofatus Naini,
  • Desi Harneti,
  • Rani Maharani,
  • Nurlelasari Nurlelasari,
  • Tri Mayanti,
  • Agus Safari,
  • Kindi Farabi,
  • Unang Supratman,
  • Mohamad Nurul Azmi,
  • Yoshihito Shiono

DOI
https://doi.org/10.22146/ijc.68383
Journal volume & issue
Vol. 21, no. 6
pp. 1560 – 1567

Abstract

Read online

Four sesquiterpenoid derivatives, i.e., 4β,10α-dihydroxyaromadendrane (1), caryophyllenol-II (2), senecrassidiol (3), and clovane-2β,9α-diol (4) have been isolated from the stem bark of Aglaia simplicifolia. The chemical structures of compounds 1-4 were determined based on spectroscopic data, including one and two-dimensional NMR and mass spectroscopy. In addition, these sesquiterpenoids 1-4, were also tested for their cytotoxic activity against B16-F10 melanoma skin cancer cell lines through in vitro assay. Among the isolated compounds 1-4, compound 1 showed the highest activity with an IC50 value of 44.8 μg/mL, suggesting the presence of a cyclopropane ring that plays an essential role in cytotoxic activity against B16-F10 melanoma skin cancer cell lines.

Keywords