Indian Journal of Ophthalmology (Jan 2015)
Bilateral optic neuropathy and intraretinal deposits after pars plana vitrectomy in amyloidosis
- Rossetti Alberto,
- Spedicato Luigi,
- Fassina Ambrogio,
- Doro Daniele
Affiliations
- Rossetti Alberto
- Spedicato Luigi
- Fassina Ambrogio
- Doro Daniele
- DOI
- https://doi.org/10.4103/0301-4738.151481
- Journal volume & issue
-
Vol. 63,
no. 1
pp. 72 – 74
Abstract
Pathological examination of material from a nonextensive pars plana vitrectomy (PPV) in the right eye provided a diagnosis of nonfamilial amyloidosis in a 68-year-old woman, who presented with bilateral glass wool-like vitreous opacities. Genetic testing revealed a Tyr114Cys mutation in the transthyretin gene. Six months after PPV, perimetry showed intense constriction with a temporal island and central scotoma in the right eye. An extensive PPV was performed in the left eye. Spectral domain optical coherence tomography evidenced bilateral epimacular amyloid deposits and unreported reflective spots within the inner retina. One year later, visual acuity had decreased to 20/400 in the left eye, with mild vitreous opacity, pale cupped optic disc and inferior altitudinal field defect. Bilateral diurnal intraocular pressure, transiently increased after PPV, never exceeded 16 mmHg with medication. Our patient presented optic nerve blood supply impairment, due to amyloidosis, which caused optic atrophy. Epiretinal and intraretinal deposit detection could aid in diagnosing patients with suspected amyloidosis.
Keywords
- Cup to disc ratio
- disc area
- glaucoma probability score
- moorfields regression analysis
- optical coherence tomography
- Antioxidant supplementation
- diabetes mellitus
- free oxygen radicals test
- nonproliferative diabetic retinopathy
- reactive oxygen species
- In vivo confocal microscopy
- keratocyte density
- prostaglandin analogues
- Chronic glaucoma patients
- economic burden
- socioeconomic profile
- Bevacizumab
- macular edema
- refractory
- retinal vein occlusion
- triamcinolone acetonide
- Corneal thickness
- menstrual cycle
- pachymetry
- refractive surgery
- Cytokines
- diabetic retinopathy
- pigment epithelium-derived factor
- vascular endothelial growth factor
- Choroidal metastases
- intravitreal bevacizumab
- transpupillary thermotherapy
- Fundus examination
- halogen light
- indirect ophthalmoscope
- light emitting diode
- photo-stress test
- Algorithm
- cross-linking
- Intacs
- keratoconus
- normogram
- Bibliometrics
- biomedical research
- journal impact factor
- ophthalmic research
- surgical research
- Aortic insufficiency
- arrhythmia
- ocular pulse amplitude
- ventricular bigeminy
- Ciliary body atrophy
- iris atrophy
- ocular hypotony
- progressive hemifacial atrophy
- Malaria fever
- microvascular occlusion
- Plasmodium falciparum
- proliferative retinopathy
- Epiretinal membrane
- stargardt disease
- vitrectomy
- Imaging
- nasal endscope
- paediatric fundus
- Heavy eye syndrome
- loop myopexy
- muscle transplantation
- Amyloidosis
- intraretinal deposits
- optic neuropathy
- optical coherence tomography
- pars plana vitrectomy
- secondary glaucoma
