Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
Yu-Te Huang,
I Wang,
Chun-Ju Lin,
Chun-Ting Lai,
Ning-Yi Hsia,
Huan-Sheng Chen,
Peng-Tai Tien,
Henry Bair,
Jane-Ming Lin,
Wen-Lu Chen,
Chang-He Chen,
Wen-Chuan Wu,
Yi-Yu Tsai
Affiliations
Yu-Te Huang
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
I Wang
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Chun-Ju Lin
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Chun-Ting Lai
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Ning-Yi Hsia
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Huan-Sheng Chen
An-Shin Dialysis Center, NephroCare Ltd., Fresenius Medical Care, Taichung 401, Taiwan
Peng-Tai Tien
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Henry Bair
Byers Eye Institute, Stanford University School of Medicine, Stanford, CA 94303, USA
Jane-Ming Lin
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Wen-Lu Chen
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Chang-He Chen
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Wen-Chuan Wu
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Yi-Yu Tsai
Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-naïve branch retinal vein occlusion (BRVO) by optical coherence tomography angiography (OCTA). Ten patients were enrolled with macular capillary density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and foveal avascular zone (FAZ) measured in both eyes before and after treatment. Final central retinal thickness and BCVA improved significantly (p p p = 0.0001, p p p p < 0.0001). OCTA offered further qualitative and quantitative evaluation of treatment-naïve BRVO. Judging by OCTA parameters, not only in the diseased eye but also in the fellow eye, DCP density of BRVO sectors was the most predictive factor of final visual outcome.
