Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study

Yu-Te Huang; I Wang; Chun-Ju Lin; Chun-Ting Lai; Ning-Yi Hsia; Huan-Sheng Chen; Peng-Tai Tien; Henry Bair; Jane-Ming Lin; Wen-Lu Chen; Chang-He Chen; Wen-Chuan Wu; Yi-Yu Tsai

doi:10.3390/medicina58040540

Medicina (Apr 2022)

Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study

Yu-Te Huang,
I Wang,
Chun-Ju Lin,
Chun-Ting Lai,
Ning-Yi Hsia,
Huan-Sheng Chen,
Peng-Tai Tien,
Henry Bair,
Jane-Ming Lin,
Wen-Lu Chen,
Chang-He Chen,
Wen-Chuan Wu,
Yi-Yu Tsai

Affiliations

Yu-Te Huang: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
I Wang: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Chun-Ju Lin: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Chun-Ting Lai: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Ning-Yi Hsia: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Huan-Sheng Chen: An-Shin Dialysis Center, NephroCare Ltd., Fresenius Medical Care, Taichung 401, Taiwan
Peng-Tai Tien: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Henry Bair: Byers Eye Institute, Stanford University School of Medicine, Stanford, CA 94303, USA
Jane-Ming Lin: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Wen-Lu Chen: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Chang-He Chen: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Wen-Chuan Wu: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Yi-Yu Tsai: Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404, Taiwan

DOI: https://doi.org/10.3390/medicina58040540
Journal volume & issue: Vol. 58, no. 4
p. 540

Abstract

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This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-naïve branch retinal vein occlusion (BRVO) by optical coherence tomography angiography (OCTA). Ten patients were enrolled with macular capillary density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and foveal avascular zone (FAZ) measured in both eyes before and after treatment. Final central retinal thickness and BCVA improved significantly (p p p = 0.0001, p p p p < 0.0001). OCTA offered further qualitative and quantitative evaluation of treatment-naïve BRVO. Judging by OCTA parameters, not only in the diseased eye but also in the fellow eye, DCP density of BRVO sectors was the most predictive factor of final visual outcome.

Published in Medicina

ISSN: 1010-660X (Print); 1648-9144 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: https://www.mdpi.com/journal/medicina

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