Nature Communications (Sep 2022)
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast
- Vincent Geldhof,
- Laura P. M. H. de Rooij,
- Liliana Sokol,
- Jacob Amersfoort,
- Maxim De Schepper,
- Katerina Rohlenova,
- Griet Hoste,
- Adriaan Vanderstichele,
- Anne-Marie Delsupehe,
- Edoardo Isnaldi,
- Naima Dai,
- Federico Taverna,
- Shawez Khan,
- Anh-Co K. Truong,
- Laure-Anne Teuwen,
- François Richard,
- Lucas Treps,
- Ann Smeets,
- Ines Nevelsteen,
- Birgit Weynand,
- Stefan Vinckier,
- Luc Schoonjans,
- Joanna Kalucka,
- Christine Desmedt,
- Patrick Neven,
- Massimiliano Mazzone,
- Giuseppe Floris,
- Kevin Punie,
- Mieke Dewerchin,
- Guy Eelen,
- Hans Wildiers,
- Xuri Li,
- Yonglun Luo,
- Peter Carmeliet
Affiliations
- Vincent Geldhof
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Laura P. M. H. de Rooij
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Liliana Sokol
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Jacob Amersfoort
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Maxim De Schepper
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven
- Katerina Rohlenova
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Griet Hoste
- Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven
- Adriaan Vanderstichele
- Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven
- Anne-Marie Delsupehe
- Department of Pathology, University Hospitals Leuven
- Edoardo Isnaldi
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven
- Naima Dai
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Federico Taverna
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Shawez Khan
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Anh-Co K. Truong
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Laure-Anne Teuwen
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- François Richard
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven
- Lucas Treps
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Ann Smeets
- Multidisciplinary Breast Centre and Department of Surgical Oncology, University Hospitals Leuven, KU Leuven
- Ines Nevelsteen
- Multidisciplinary Breast Centre and Department of Surgical Oncology, University Hospitals Leuven, KU Leuven
- Birgit Weynand
- Department of Pathology, University Hospitals Leuven
- Stefan Vinckier
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Luc Schoonjans
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Joanna Kalucka
- Aarhus University of Advanced Studies (AIAS), Aarhus University
- Christine Desmedt
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven
- Patrick Neven
- Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven
- Massimiliano Mazzone
- Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of oncology, KU Leuven
- Giuseppe Floris
- Department of Pathology, University Hospitals Leuven
- Kevin Punie
- Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven
- Mieke Dewerchin
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Guy Eelen
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- Hans Wildiers
- Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven
- Xuri Li
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
- Yonglun Luo
- Department of Biomedicine, Aarhus University
- Peter Carmeliet
- Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven
- DOI
- https://doi.org/10.1038/s41467-022-33052-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Tumor blood vessels contribute to cancer growth, invasion and metastasis. Here, by using single cell transcriptomics, the authors report an inventory of endothelial cell heterogeneity in patients with breast cancer, including a subtype that expresses genes involved in lipid processing and is regulated by PPAR-γ.
