Frontiers in Bioengineering and Biotechnology (Nov 2024)
Modular design workflow for 3D printable bioresorbable patient-specific bone scaffolds: extended features and clinical validation
- Buddhi Herath,
- Buddhi Herath,
- Buddhi Herath,
- Buddhi Herath,
- Markus Laubach,
- Markus Laubach,
- Markus Laubach,
- Markus Laubach,
- Sinduja Suresh,
- Sinduja Suresh,
- Sinduja Suresh,
- Sinduja Suresh,
- Beat Schmutz,
- Beat Schmutz,
- Beat Schmutz,
- Beat Schmutz,
- J. Paige Little,
- J. Paige Little,
- J. Paige Little,
- J. Paige Little,
- Prasad K. D. V. Yarlagadda,
- Prasad K. D. V. Yarlagadda,
- Prasad K. D. V. Yarlagadda,
- Heide Delbrück,
- Frank Hildebrand,
- Dietmar W. Hutmacher,
- Dietmar W. Hutmacher,
- Dietmar W. Hutmacher,
- Dietmar W. Hutmacher,
- Marie-Luise Wille,
- Marie-Luise Wille,
- Marie-Luise Wille,
- Marie-Luise Wille
Affiliations
- Buddhi Herath
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Buddhi Herath
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Buddhi Herath
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Buddhi Herath
- Jamieson Trauma Institute, Metro North Hospital and Health Service, Brisbane, Australia
- Markus Laubach
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Markus Laubach
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Markus Laubach
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Markus Laubach
- Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany
- Sinduja Suresh
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Sinduja Suresh
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Sinduja Suresh
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Sinduja Suresh
- Biomechanics and Spine Research Group at the Centre for Children’s Health Research, Queensland University of Technology, Brisbane, Australia
- Beat Schmutz
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Beat Schmutz
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Beat Schmutz
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Beat Schmutz
- Jamieson Trauma Institute, Metro North Hospital and Health Service, Brisbane, Australia
- J. Paige Little
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- J. Paige Little
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- J. Paige Little
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- J. Paige Little
- Biomechanics and Spine Research Group at the Centre for Children’s Health Research, Queensland University of Technology, Brisbane, Australia
- Prasad K. D. V. Yarlagadda
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Prasad K. D. V. Yarlagadda
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Prasad K. D. V. Yarlagadda
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Heide Delbrück
- Department of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
- Frank Hildebrand
- Department of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
- Dietmar W. Hutmacher
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Dietmar W. Hutmacher
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Dietmar W. Hutmacher
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Dietmar W. Hutmacher
- Max Planck Queensland Centre for the Materials Science of Extracellular Matrices, Queensland University of Technology, Brisbane, Australia
- Marie-Luise Wille
- Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia
- Marie-Luise Wille
- Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia
- Marie-Luise Wille
- School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia
- Marie-Luise Wille
- Max Planck Queensland Centre for the Materials Science of Extracellular Matrices, Queensland University of Technology, Brisbane, Australia
- DOI
- https://doi.org/10.3389/fbioe.2024.1404481
- Journal volume & issue
-
Vol. 12
Abstract
A previously in-house developed patient-specific scaffold design workflow was extended with new features to overcome several limitations and to broaden its adaptability to diverse bone defects, thereby enhancing its fit for routine clinical use. It was applied to three clinical cases for further validation. A virtual surgical resection tool was developed to remove regions of the bone defect models. The minor cavity fill module enabled the generation of scaffold designs with smooth external surfaces and the segmental defect fill module allowed a versatile method to fill a segmental defect cavity. The boundary representation method based surgical approach module in the original workflow was redeveloped to use functional representation, eliminating previously seen resolution dependant artefacts. Lastly, a method to overlay the scaffold designs on computed tomography images of the defect for design verification by the surgeon was introduced. The extended workflow was applied to two ongoing clinical case studies of a complex bilateral femoral defect and a humerus defect, and also to a case of a large volume craniomaxillofacial defect. It was able to successfully generate scaffolds without any obstructions to their surgical insertion which was verified by digital examination as well as using physical 3D printed models. All produced surface meshes were free from 3D printing mesh errors. The scaffolds designed for the ongoing cases were 3D printed and successfully surgically implanted, providing confidence in the extended modular workflow’s ability to be applied to a broad range of diverse clinical cases.
Keywords
- scaffold-guided bone regeneration
- scaffold design workflow
- additive manufacturing
- generative design
- parametric design
