Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1

Ashley K. Wiseman; Rochelle L. Tiedemann; Huihui Fan; Hui Shen; Zachary Madaj; Michael T. McCabe; Melissa B. Pappalardi; Peter A. Jones

doi:10.1038/s42003-022-03509-3

Communications Biology (Jun 2022)

Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1

Ashley K. Wiseman,
Rochelle L. Tiedemann,
Huihui Fan,
Hui Shen,
Zachary Madaj,
Michael T. McCabe,
Melissa B. Pappalardi,
Peter A. Jones

Affiliations

Ashley K. Wiseman: Department of Epigenetics, Van Andel Institute
Rochelle L. Tiedemann: Department of Epigenetics, Van Andel Institute
Huihui Fan: Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
Hui Shen: Department of Epigenetics, Van Andel Institute
Zachary Madaj: Department of Epigenetics, Van Andel Institute
Michael T. McCabe: Cancer Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline
Melissa B. Pappalardi: Cancer Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline
Peter A. Jones: Department of Epigenetics, Van Andel Institute

DOI: https://doi.org/10.1038/s42003-022-03509-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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Chromosome specific retention of cancer associated DNA hypermethylation following pharmacological inhibition of DNMT1 is shown, with residual CpG methylation on the X chromosome compared to autosomes, suggesting a separate mechanism of methylation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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