Nature Communications (Sep 2017)
Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography
- Martin Thunemann,
- Barbara F. Schörg,
- Susanne Feil,
- Yun Lin,
- Jakob Voelkl,
- Matthias Golla,
- Angelos Vachaviolos,
- Ursula Kohlhofer,
- Leticia Quintanilla-Martinez,
- Marcus Olbrich,
- Walter Ehrlichmann,
- Gerald Reischl,
- Christoph M. Griessinger,
- Harald F. Langer,
- Meinrad Gawaz,
- Florian Lang,
- Michael Schäfers,
- Manfred Kneilling,
- Bernd J. Pichler,
- Robert Feil
Affiliations
- Martin Thunemann
- Interfakultäres Institut für Biochemie, University of Tübingen
- Barbara F. Schörg
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Susanne Feil
- Interfakultäres Institut für Biochemie, University of Tübingen
- Yun Lin
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Jakob Voelkl
- Physiologisches Institut I, University of Tübingen
- Matthias Golla
- Interfakultäres Institut für Biochemie, University of Tübingen
- Angelos Vachaviolos
- Interfakultäres Institut für Biochemie, University of Tübingen
- Ursula Kohlhofer
- Institute of Pathology and Neuropathology, University of Tübingen, and Comprehensive Cancer Center, University Hospital
- Leticia Quintanilla-Martinez
- Institute of Pathology and Neuropathology, University of Tübingen, and Comprehensive Cancer Center, University Hospital
- Marcus Olbrich
- Department of Cardiovascular Medicine, University Hospital, University of Tübingen
- Walter Ehrlichmann
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Gerald Reischl
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Christoph M. Griessinger
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Harald F. Langer
- Department of Cardiovascular Medicine, University Hospital, University of Tübingen
- Meinrad Gawaz
- Department of Cardiovascular Medicine, University Hospital, University of Tübingen
- Florian Lang
- Physiologisches Institut I, University of Tübingen
- Michael Schäfers
- Department of Nuclear Medicine, University Hospital, European Institute for Molecular Imaging & EXC 1003 Cells-in-Motion Cluster of Excellence, University of Münster
- Manfred Kneilling
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Bernd J. Pichler
- Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen
- Robert Feil
- Interfakultäres Institut für Biochemie, University of Tübingen
- DOI
- https://doi.org/10.1038/s41467-017-00482-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Non-invasive cell tracking is a powerful method to visualize cells in vivo under physiological and pathophysiological conditions. Here Thunemann et al. generate a mouse model for in vivo tracking and quantification of specific cell types by combining a PET reporter gene with Cre-dependent activation that can be exploited for any cell population for which a Cre mouse line is available.
