Current Trends in Intensive Care of Eclampic Coma

Abstract

Objective: to define the efficiency of the intensive care priorities of eclampic coma, which reduce mortality in puer-peras, by studying systemic and metabolic disturbances. Subjects and methods. Studies were conducted in 42 puer-peras with eclampic coma (a study group) in whom the authors used their intensive care algorithm the basis for which was standard (conventional) therapy. Central hemodynamic parameters were studied by the direct method of right heart catheterization using a flow-directed Swan-Ganz catheter. Overall cerebral blood flow was measured by a noninvasive (inhalation) radionuclide method, by using the tracer 133Xe, as described by V. D. Obrist et al., on a modified КПРДИ-1 apparatus (USSR). The rate of brain oxygen uptake was determined from the oxygen content between the artery and the internal jugular vein. Studies were made in four steps: 1) on admission; 2) on days 2—3; 3) emergence from coma; 4) before transition. Results. The use of the authors’ proposed algorithm of intensive care for eclampic coma, which is aimed at enhancing cerebral blood flow due to the slight expanding effect of stabizole and antihypertensive therapy (nimodipine and magnesium sulfate), lowered the mean arterial pressure by not more than 10—25% of the baseline level. Conclusion. The proposed intensive care could reduce mortality by up to 4.8%. Key words: eclampsia, eclampic coma, intensive care.