After global health catastrophe due to Coronavirus disease-2019 (COVID-19), a deep impact on the way we perceive our world and our everyday lives has been imprinted. Till now, no specific antiviral drug has been proven effective for curing patients. Ivermectin, the broad-spectrum macrocyclic lactone has proven to exert antiviral activity against human immunodeficiency virus (HIV), dengue virus and now capability to reduce viral RNA up to 5,000-fold after 48 h of infection with SARS-CoV-2.