Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials

Boying Li; Ning Li; Nana Wang; Chaoqun Li; Xiaoning Liu; Zhanshuo Cao; Chengfen Xing; Shu Wang

Materials Today Advances (Mar 2023)

Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials

Boying Li,
Ning Li,
Nana Wang,
Chaoqun Li,
Xiaoning Liu,
Zhanshuo Cao,
Chengfen Xing,
Shu Wang

Affiliations

Boying Li: School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, PR China
Ning Li: School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, PR China
Nana Wang: School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, PR China
Chaoqun Li: School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, PR China
Xiaoning Liu: School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, PR China
Zhanshuo Cao: School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, PR China
Chengfen Xing: School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, PR China; School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, PR China; Corresponding author. School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, PR China.
Shu Wang: Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China; Corresponding author.

Journal volume & issue: Vol. 17
p. 100335

Abstract

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Reactive oxygen species (ROS) play an important role in regulating various physiological functions by activating specific ion channels to mediate cell growth, proliferation, regeneration, and apoptosis. ROS sensitive ion channels in the transient receptor potential (TRP) channel family are closely related to oxidative stress-related diseases. Therefore, it is of great significance to regulate ROS levels and their related ion channels. This review summarizes the role of five ROS sensitive ion channels, transient receptor potential M2 (TRPM2), transient receptor potential A1 (TRPA1), transient receptor potential V1 (TRPV1), transient receptor potential M7 (TRPM7) and transient receptor potential C5 (TRPC5), in oxidative stress-related diseases. In addition, the recent research progress of using nanomaterials to regulate oxidative stress-related diseases by targeting ROS-sensitive ion channels is summarized. It is hoped that this review will provide insights for researchers to regulate ROS-sensitive ion channels to alleviate related diseases.

Published in Materials Today Advances

ISSN: 2590-0498 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-today-advances

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