Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Caroline Araiz; Anqi Yan; Lucia Bettedi; Isabella Samuelson; Sam Virtue; Anne K. McGavigan; Christian Dani; Antonio Vidal-Puig; Lazaros C. Foukas

doi:10.1038/s41467-019-09514-1

Nature Communications (Apr 2019)

Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Caroline Araiz,
Anqi Yan,
Lucia Bettedi,
Isabella Samuelson,
Sam Virtue,
Anne K. McGavigan,
Christian Dani,
Antonio Vidal-Puig,
Lazaros C. Foukas

Affiliations

Caroline Araiz: Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College London
Anqi Yan: Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College London
Lucia Bettedi: Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College London
Isabella Samuelson: Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College London
Sam Virtue: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Anne K. McGavigan: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Christian Dani: Université Côte d’Azur, CNRS, Inserm, iBV, Faculté de Médecine
Antonio Vidal-Puig: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Lazaros C. Foukas: Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College London

DOI: https://doi.org/10.1038/s41467-019-09514-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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