Nature Communications (Jan 2020)
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
- Ning Li,
- Anuradha Kalyanasundaram,
- Brian J. Hansen,
- Esthela J. Artiga,
- Roshan Sharma,
- Suhaib H. Abudulwahed,
- Katelynn M. Helfrich,
- Galina Rozenberg,
- Pei-Jung Wu,
- Stanislav Zakharkin,
- Sandor Gyorke,
- Paul ML. Janssen,
- Bryan A. Whitson,
- Nahush A. Mokadam,
- Brandon J. Biesiadecki,
- Federica Accornero,
- John D. Hummel,
- Peter J. Mohler,
- Halina Dobrzynski,
- Jichao Zhao,
- Vadim V. Fedorov
Affiliations
- Ning Li
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Anuradha Kalyanasundaram
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Brian J. Hansen
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Esthela J. Artiga
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Roshan Sharma
- Auckland Bioengineering Institute, The University of Auckland
- Suhaib H. Abudulwahed
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Katelynn M. Helfrich
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Galina Rozenberg
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Pei-Jung Wu
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Stanislav Zakharkin
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Sandor Gyorke
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Paul ML. Janssen
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Bryan A. Whitson
- Bob and Corrine Frick Center for Heart Failure and Arrhythmia, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center
- Nahush A. Mokadam
- Bob and Corrine Frick Center for Heart Failure and Arrhythmia, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center
- Brandon J. Biesiadecki
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Federica Accornero
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- John D. Hummel
- Bob and Corrine Frick Center for Heart Failure and Arrhythmia, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center
- Peter J. Mohler
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- Halina Dobrzynski
- Division of Cardiovascular Sciences, The University of Manchester
- Jichao Zhao
- Auckland Bioengineering Institute, The University of Auckland
- Vadim V. Fedorov
- Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-14039-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their alterations in explanted human diseased hearts.
