Nature Communications (Dec 2016)

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

  • Daniela Chmiest,
  • Nanaocha Sharma,
  • Natacha Zanin,
  • Christine Viaris de Lesegno,
  • Massiullah Shafaq-Zadah,
  • Vonick Sibut,
  • Florent Dingli,
  • Philippe Hupé,
  • Stephan Wilmes,
  • Jacob Piehler,
  • Damarys Loew,
  • Ludger Johannes,
  • Gideon Schreiber,
  • Christophe Lamaze

DOI
https://doi.org/10.1038/ncomms13476
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this controls JAK/STAT signalling and gene transcription.