Nature Communications (Mar 2023)
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model
- Stefano Suzzi,
- Tommaso Croese,
- Adi Ravid,
- Or Gold,
- Abbe R. Clark,
- Sedi Medina,
- Daniel Kitsberg,
- Miriam Adam,
- Katherine A. Vernon,
- Eva Kohnert,
- Inbar Shapira,
- Sergey Malitsky,
- Maxim Itkin,
- Alexander Brandis,
- Tevie Mehlman,
- Tomer M. Salame,
- Sarah P. Colaiuta,
- Liora Cahalon,
- Michal Slyper,
- Anna Greka,
- Naomi Habib,
- Michal Schwartz
Affiliations
- Stefano Suzzi
- Weizmann Institute of Science, Department of Brain Sciences
- Tommaso Croese
- Weizmann Institute of Science, Department of Brain Sciences
- Adi Ravid
- The Hebrew University of Jerusalem, Edmond & Lily Safra Center for Brain Sciences
- Or Gold
- The Hebrew University of Jerusalem, Edmond & Lily Safra Center for Brain Sciences
- Abbe R. Clark
- Broad Institute of MIT and Harvard
- Sedi Medina
- Weizmann Institute of Science, Department of Brain Sciences
- Daniel Kitsberg
- The Hebrew University of Jerusalem, Edmond & Lily Safra Center for Brain Sciences
- Miriam Adam
- The Hebrew University of Jerusalem, Edmond & Lily Safra Center for Brain Sciences
- Katherine A. Vernon
- Broad Institute of MIT and Harvard
- Eva Kohnert
- Broad Institute of MIT and Harvard
- Inbar Shapira
- The Hebrew University of Jerusalem, Edmond & Lily Safra Center for Brain Sciences
- Sergey Malitsky
- Weizmann Institute of Science, Life Sciences Core Facilities
- Maxim Itkin
- Weizmann Institute of Science, Life Sciences Core Facilities
- Alexander Brandis
- Weizmann Institute of Science, Life Sciences Core Facilities
- Tevie Mehlman
- Weizmann Institute of Science, Life Sciences Core Facilities
- Tomer M. Salame
- Weizmann Institute of Science, Life Sciences Core Facilities
- Sarah P. Colaiuta
- Weizmann Institute of Science, Department of Brain Sciences
- Liora Cahalon
- Weizmann Institute of Science, Department of Brain Sciences
- Michal Slyper
- Broad Institute of MIT and Harvard
- Anna Greka
- Broad Institute of MIT and Harvard
- Naomi Habib
- The Hebrew University of Jerusalem, Edmond & Lily Safra Center for Brain Sciences
- Michal Schwartz
- Weizmann Institute of Science, Department of Brain Sciences
- DOI
- https://doi.org/10.1038/s41467-023-36759-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit.
