Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures

Somin Lee; Sarita S. Deshpande; Edward M. Merricks; Emily Schlafly; Robert Goodman; Guy M. McKhann; Emad N. Eskandar; Joseph R. Madsen; Sydney S. Cash; Michel J. A. M. van Putten; Catherine A. Schevon; Wim van Drongelen

doi:10.1038/s42003-023-04696-3

Communications Biology (Mar 2023)

Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures

Somin Lee,
Sarita S. Deshpande,
Edward M. Merricks,
Emily Schlafly,
Robert Goodman,
Guy M. McKhann,
Emad N. Eskandar,
Joseph R. Madsen,
Sydney S. Cash,
Michel J. A. M. van Putten,
Catherine A. Schevon,
Wim van Drongelen

Affiliations

Somin Lee: Department of Pediatrics, University of Chicago
Sarita S. Deshpande: Department of Pediatrics, University of Chicago
Edward M. Merricks: Department of Neurology, Columbia University
Emily Schlafly: Graduate Program in Neuroscience, Boston University
Robert Goodman: Department of Neurosurgery, Lenox Hill Hospital
Guy M. McKhann: Department of Neurological Surgery, Columbia University
Emad N. Eskandar: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School
Joseph R. Madsen: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School
Sydney S. Cash: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Michel J. A. M. van Putten: Clinical Neurophysiology Group, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente
Catherine A. Schevon: Department of Neurology, Columbia University
Wim van Drongelen: Department of Pediatrics, University of Chicago

DOI: https://doi.org/10.1038/s42003-023-04696-3
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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Spatiotemporal spike-centered averaging (st-SCA) allows for the visualization of spike-local field potential relationships across both temporal and spatial domains from microelectrode array recordings.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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