Prioritizing risk genes as novel stratification biomarkers for acute monocytic leukemia by integrative analysis

Hang He; Zhiqin Wang; Hanzhi Yu; Guorong Zhang; Yuchen Wen; Zhigang Cai

doi:10.1007/s12672-022-00516-y

Discover Oncology (Jun 2022)

Prioritizing risk genes as novel stratification biomarkers for acute monocytic leukemia by integrative analysis

Hang He,
Zhiqin Wang,
Hanzhi Yu,
Guorong Zhang,
Yuchen Wen,
Zhigang Cai

Affiliations

Hang He: The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University
Zhiqin Wang: The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University
Hanzhi Yu: The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University
Guorong Zhang: The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University
Yuchen Wen: The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University
Zhigang Cai: The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University

DOI: https://doi.org/10.1007/s12672-022-00516-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Key points 1. t-SNE instructed transcriptomic stratification discriminates FAB subgroups of AML. 2. Potential association of the prioritized genes with Venetoclax resistance at single-cell resolution.

Published in Discover Oncology

ISSN: 2730-6011 (Online)
Publisher: Springer
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.springer.com/journal/12672/

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Abstract

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